Obtaining extremely large and accurate protein multiple sequence alignments from curated hierarchical alignments
نویسندگان
چکیده
منابع مشابه
PROMALS web server for accurate multiple protein sequence alignments
Multiple sequence alignments are essential in homology inference, structure modeling, functional prediction and phylogenetic analysis. We developed a web server that constructs multiple protein sequence alignments using PROMALS, a progressive method that improves alignment quality by using additional homologs from PSI-BLAST searches and secondary structure predictions from PSIPRED. PROMALS show...
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We have studied the question of how much extra predictive power the correlated mutational behaviour of pairs of amino acid residues separated along a sequence has concerning the likelihood of those residues being in contact in the folded protein. The mutational behaviour is deduced from multiple sequence alignments. Our findings are that there is, indeed, some valuable information available fro...
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ژورنال
عنوان ژورنال: Database
سال: 2020
ISSN: 1758-0463
DOI: 10.1093/database/baaa042